The current research was carried out with the aim of designing a model of how to influence the phenomenon of organizational ghosts in government organizations with the ISM approach. This research is applied in terms of purpose and descriptive survey in terms of nature and method. The statistical population of the research is the managers of government organizations, 20 of whom were selected using the purposeful sampling method. The data collection tool is an interview in the qualitative part and a questionnaire in the quantitative part, the validity and reliability of which were confirmed using the content method and theoretical validity and intra-coder and inter-coder reliability. To analyze the data in the qualitative part, the content analysis method was used using MAXQDA software, and in the quantitative part, interpretive structural modeling and MATLAB software were used. The results of the research showed that the factors affecting the phenomenon of organizational ghosts in four axes are the foundational factors of the phenomenon of organizational ghosts, the reinforcements of the phenomenon of organizational ghosts, the dimensions of the phenomenon of organizational ghosts and finally the consequences of the phenomenon of organizational ghosts. Based on the results, the dimensions of the phenomenon of organizational ghosts should be carefully managed and considered in order not only to make maximum use of positive legacies, but also to avoid negative consequences. Finally, the ability of new managers to interact with these dimensions can contribute to the sustainable success of the organization.