The main purpose of this study was to investigate of the influence of knowledge management on entrepreneurial opportunities recognition in the Agricultural and Natural Resources Campus (ANRC) of Tehran University. The statistical population of this research contained 250 faculty members of agricultural majors of the campus. A sample of 147 faculty members was selected with Cochran formula, using "stratified proportional sampling" method. A questionnaire was used to collect the data. The content validity of the questionnaire was confirmed by a panel of experts. A pilot study was conducted to establish reliability of the instrument. Cronbach 's alpha coefficient for the main scales of the questionnaire was higher than 0.75. The collected data were analyzed using SPSS and LISREL software. According to the results, knowledge sharing, Knowledge acquisition, and Knowledge utilization are the most important components of knowledge management. Also result indicated that most important components of entrepreneurial opportunities recognition are Imitation opportunities, Incremental opportunities, and Innovative opportunities. Results showed that the knowledge management has a positive and significant impact on the entrepreneurial opportunities recognition in University College of Agriculture and Natural Resources University of Tehran.